Poor relationship between arterial [lactate] and leg net release during exercise at 4,300 m altitude.

نویسندگان

  • George A Brooks
  • Eugene E Wolfel
  • Gail E Butterfield
  • Allen Cymerman
  • Amy C Roberts
  • Robert S Mazzeo
  • John T Reeves
چکیده

We evaluated the hypotheses that on acute exposure to hypobaric hypoxia, sympathetic stimulation leads to augmented muscle lactate production and circulating [lactate] through a β-adrenergic mechanism and that β-adrenergic adaptation to chronic hypoxia is responsible for the blunted exercise lactate response after acclimatization to altitude. Five control and 6 β-blocked men were studied during rest and exercise at sea level (SL), on acute exposure to 4,300 m (A1), and after a 3-wk sojourn at altitude (A2). Exercise was by leg cycling at 49% of SL peak O2 consumption (V˙o 2 peak) (65% of altitude V˙o 2 peak or 87 ± 2.6 W); β-blockade was by propranolol (80 mg 3× daily), femoral arterial and venous blood was sampled; leg blood flow (Q˙) was measured by thermodilution, leg lactate net release [L˙ = (2) (1-leg Q) venous-arterial concentrationL] was calculated, and vastus lateralis needle biopsies were obtained. Muscle [lactate] increased with exercise and acute altitude exposure but regressed to SL values with acclimatization; β-blockade had no effect on muscle [lactate]. Arterial [lactate] rose during exercise at SL (0.9 ± 0.1 to 1.5 ± 0.3 mM); exercise at A1 produced the greatest arterial [lactate] (4.4 ± 0.8 mM), and exercise at A2 an intermediate response (2.1 ± 0.6 mM). β-Blockade reduced circulating [lactate] ∼45% during exercise under all altitude conditions. L˙ increased transiently at exercise onset but then declined over time under all conditions. Blood and muscle "lactate paradoxes" occurred independent of β-adrenergic influences, and the hypotheses relating the blood lactate response at altitude to β-adrenergic mechanisms are rejected. During exercise at altitude, arterial [lactate] is determined by factors in addition to hypoxemia, circulating epinephrine, and net lactate release from active muscle beds.

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عنوان ژورنال:
  • The American journal of physiology

دوره 275 4 Pt 2  شماره 

صفحات  -

تاریخ انتشار 1998